Search strategy Related studies, from inception to July 6, 2025, were systematically retrieved from electronic databases (CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase (via Ovid), Cochrane library, Web of Science), grey literature (Open Grey and Proquest), and reference lists of included articles were searched
1,5 Because glucomannan rapidly expands after absorbing water, insufficient fluid intake may increase the risk of choking or esophageal and intestinal obstruction, particularly with tablet formulations
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Even when discounts are available, coverage is increasingly restricted by: Strict prior authorization requirements Step-therapy mandates Employer plan exclusions State Medicaid budget limitations Data also shows that many patients regain weight after stopping GLP-1 medications, reinforcing concerns that these drugs may function more as a long-term maintenance therapy rather than a finite treatment
